Side Effects:
When taken by mouth: Tianeptine is possibly unsafe. While tianeptine is available by prescription in certain countries, it has a risk of misuse and abuse. Taking high doses of tianeptine can cause drowsiness, confusion, difficulty breathing, coma, and death. Long-term use can cause dependence and withdrawal.
Special Precautions and Warnings:
When taken by mouth: Tianeptine is possibly unsafe. While tianeptine is available by prescription in certain countries, it has a risk of misuse and abuse. Taking high doses of tianeptine can cause drowsiness, confusion, difficulty breathing, coma, and death. Long-term use can cause dependence and withdrawal.
Pregnancy: Tianeptine is possibly unsafe when taken by mouth during pregnancy. It can cause the infant to be born addicted to tianeptine.
Breast-feeding: There isn’t enough reliable information about the safety of tianeptine when breast-feeding. But other drugs that are similar to tianeptine are known to enter the breastmilk. Stay on the safe side and avoid use.
History of substance use disorder: Using tianeptine for a long time can cause dependence and withdrawal, especially in people that have a history of substance use disorder.
Surgery: High doses of tianeptine might have sedative effects. Anesthesia and other medications used during and after surgery might increase this effect. Stop taking tianeptine at least 2 weeks before a scheduled surgery.
Interactions:
Tianeptine contains a chemical that affects the body. This chemical might increase serious side effects of some medications used for depression.
Some common MAOIs include phenelzine (Nardil), selegiline (Zelapar), and tranylcypromine (Parnate).
Moderate Interaction:
Alcohol can decrease how quickly the body breaks down tianeptine. Taking tianeptine along with alcohol might increase the levels of tianeptine in the body and increase the risk for side effects.
Long-term aspirin use might increase the levels of tianeptine in the body. This can increase the risk of side effects from tianeptine.
Tianeptine might cause sleepiness and slowed breathing. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Taking tianeptine with sedative medications might cause breathing problems and/or too much sleepiness.
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